| id | GO:0000155 Detailed information
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| name | two-component sensor activity
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| namespace | molecular_function
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| def | "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
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| subset | gosubset_prok
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| synonym | "two-component sensor molecule" NARROW []
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| synonym | "two-component system sensor activity " EXACT []
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| xref | EC:2.7.3.-
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| is_a | GO:0004673 ! protein histidine kinase activity
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| is_a | GO:0004871 ! signal transducer activity
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| relationship | part_of GO:0000160 ! two-component signal transduction system (phosphorelay)
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