| id | GO:0000165 Detailed information
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| name | MAPKKK cascade
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| namespace | biological_process
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| def | "A series of protein phosphorylation events catalyzed by MAP kinases, by which a signal is passed on to downstream components within a cell. The MAPKKK cascade begins with phosphorylation of a MAPKK by a MAPKKK, and ends with phosphorylation of a downstream target by MAPK." [GOC:bf, GOC:mtg_signaling_feb11, PMID:9561267]
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| synonym | "ERK/MAPK cascade" EXACT []
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| synonym | "MAP kinase cascade" EXACT []
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| synonym | "MAP kinase kinase kinase cascade" EXACT []
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| synonym | "MAPK cascade" EXACT []
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| synonym | "MAPK signaling" RELATED []
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| synonym | "MAPK signalling" RELATED []
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| synonym | "MAPKKK cascade during sporulation" NARROW []
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| xref | Reactome:109869 "MAP kinase cascade"
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| xref | Reactome:1253131 "MAP kinase cascade"
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| xref | Reactome:1280065 "MAP kinase cascade"
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| xref | Reactome:1298946 "MAP kinase cascade"
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| xref | Reactome:1326636 "MAP kinase cascade"
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| xref | Reactome:1352748 "MAP kinase cascade"
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| xref | Reactome:1372959 "MAP kinase cascade"
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| xref | Reactome:1392975 "MAP kinase cascade"
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| xref | Reactome:1417455 "MAP kinase cascade"
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| xref | Reactome:1450548 "MAP kinase cascade"
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| xref | Reactome:1471047 "MAP kinase cascade"
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| xref | Reactome:1483063 "MAP kinase cascade"
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| xref | Reactome:1526784 "MAP kinase cascade"
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| xref | Reactome:1532510 "MAP kinase cascade"
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| xref | Wikipedia:MAPK_cascade
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| xref | Wikipedia:Mitogen-activated_protein_kinase
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| is_a | GO:0007243 ! intracellular protein kinase cascade
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