| id | GO:0000398 Detailed information
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| name | nuclear mRNA splicing, via spliceosome
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| namespace | biological_process
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| alt_id | GO:0006374
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| alt_id | GO:0006375
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| def | "The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0879695897]
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| comment | Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
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| synonym | "mRNA splicing" BROAD []
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| synonym | "nuclear mRNA splicing via U12-type spliceosome" NARROW []
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| synonym | "nuclear mRNA splicing via U2-type spliceosome" NARROW []
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| synonym | "pre-mRNA splicing" BROAD []
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| synonym | "splicing AT-AC intron" RELATED []
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| synonym | "splicing GT-AG intron" RELATED []
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| xref | Reactome:1252971 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1253042 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1279901 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1279974 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1326474 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1326547 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1352588 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1352659 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1372813 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1372875 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1417301 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1417366 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1450391 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1450467 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1470918 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1470984 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1482955 "mRNA Splicing - Major Pathway"
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| xref | Reactome:1483014 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1496781 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1514171 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1521006 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1532471 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:1536011 "mRNA Splicing - Minor Pathway"
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| xref | Reactome:72163 "mRNA Splicing - Major Pathway"
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| xref | Reactome:72165 "mRNA Splicing - Minor Pathway"
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| is_a | GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
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| is_a | GO:0006397 ! mRNA processing
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