| id | GO:0002224 Detailed information
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| name | toll-like receptor signaling pathway
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| namespace | biological_process
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| def | "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
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| comment | This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
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| synonym | "TLR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"]
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| synonym | "toll-like receptor signalling pathway" EXACT []
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| xref | Reactome:1253149 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1280083 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1298965 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1326654 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1352766 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1372977 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1392993 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1417473 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1450566 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1471073 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1483089 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1496964 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1514351 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1521223 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1526812 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:1532538 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:168188 "Toll Like Receptor TLR6:TLR2 Cascade"
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| xref | Reactome:437987 "Innate immune response mediated by toll like receptors"
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| is_a | GO:0002221 ! pattern recognition receptor signaling pathway
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