| id | GO:0003810 Detailed information
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| name | protein-glutamine gamma-glutamyltransferase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
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| subset | gosubset_prok
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| synonym | "factor XIIIa" RELATED [EC:2.3.2.13]
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| synonym | "fibrin stabilizing factor" RELATED [EC:2.3.2.13]
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| synonym | "fibrinoligase activity" EXACT []
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| synonym | "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13]
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| synonym | "polyamine transglutaminase activity" RELATED [EC:2.3.2.13]
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| synonym | "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13]
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| synonym | "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13]
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| synonym | "TGase activity" EXACT []
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| synonym | "tissue transglutaminase" NARROW [EC:2.3.2.13]
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| synonym | "transglutaminase activity" EXACT []
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| xref | EC:2.3.2.13
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| xref | MetaCyc:2.3.2.13-RXN
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| xref | Reactome:11549 "protein-glutamine gamma-glutamyltransferase activity"
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| xref | RESID:AA0124
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| is_a | GO:0016755 ! transferase activity, transferring amino-acyl groups
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