| id | GO:0004129 Detailed information
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| name | cytochrome-c oxidase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
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| comment | The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
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| subset | gosubset_prok
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| synonym | "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
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| synonym | "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
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| synonym | "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
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| synonym | "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
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| synonym | "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1]
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| synonym | "cytochrome a3 activity" NARROW [EC:1.9.3.1]
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| synonym | "cytochrome aa3 activity" NARROW [EC:1.9.3.1]
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| synonym | "cytochrome oxidase activity" RELATED [EC:1.9.3.1]
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| synonym | "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1]
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| synonym | "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1]
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| synonym | "indophenol oxidase" NARROW [EC:1.9.3.1]
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| synonym | "indophenolase" NARROW [EC:1.9.3.1]
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| synonym | "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1]
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| synonym | "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1]
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| xref | EC:1.9.3.1
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| xref | MetaCyc:CYTOCHROME-C-OXIDASE-RXN
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| xref | Reactome:8283 "cytochrome-c oxidase activity"
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| is_a | GO:0015002 ! heme-copper terminal oxidase activity
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| is_a | GO:0015078 ! hydrogen ion transmembrane transporter activity
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| is_a | GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
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