| id | GO:0004421 Detailed information
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| name | hydroxymethylglutaryl-CoA synthase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10191]
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| comment | Note that this function was formerly EC:4.1.3.5.
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| subset | gosubset_prok
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| synonym | "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10]
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| synonym | "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10]
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| synonym | "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10]
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| synonym | "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10]
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| synonym | "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10]
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| synonym | "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10]
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| synonym | "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10]
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| synonym | "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10]
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| synonym | "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10]
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| synonym | "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10]
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| synonym | "HMG-CoA synthase activity" EXACT [EC:2.3.3.10]
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| synonym | "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10]
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| synonym | "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10]
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| synonym | "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10]
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| xref | EC:2.3.3.10
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| xref | KEGG:R01978
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| xref | MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
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| xref | Reactome:74169 "hydroxymethylglutaryl-CoA synthase activity"
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| xref | RHEA:10191
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| is_a | GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
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