| id | GO:0004662 Detailed information
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| name | CAAX-protein geranylgeranyltransferase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
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| synonym | "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
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| synonym | "geranylgeranyltransferase type I activity" EXACT []
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| synonym | "GGTase-I activity" EXACT []
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| synonym | "GGTaseI activity" EXACT []
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| synonym | "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59]
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| synonym | "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59]
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| xref | EC:2.5.1.59
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| xref | MetaCyc:2.5.1.60-RXN
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| xref | MetaCyc:RXN-3701
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| is_a | GO:0004661 ! protein geranylgeranyltransferase activity
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