id | GO:0005044   Detailed information |
---|---|
  name | scavenger receptor activity |
  namespace | molecular_function |
  def | "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization." [GOC:bf, GOC:signaling, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] |
  comment | Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. |
  subset | gosubset_prok |
  synonym | "macrophage receptor activity" NARROW [] |
  is_a | GO:0004888 ! transmembrane receptor activity |
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