| id | GO:0008384 Detailed information
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| name | IkappaB kinase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10]
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| comment | Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. The kinase is composed of alpha, beta and gamma subunits, of which the latter does not have kinase activity but is presumed to play a regulatory role.
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| synonym | "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10]
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| synonym | "CHUK" RELATED [EC:2.7.11.10]
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| synonym | "ikappaB kinase activity" EXACT [EC:2.7.11.10]
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| synonym | "IKBKA" RELATED [EC:2.7.11.10]
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| synonym | "IKBKB" RELATED [EC:2.7.11.10]
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| synonym | "IKK" RELATED [EC:2.7.11.10]
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| synonym | "IKK-1" RELATED [EC:2.7.11.10]
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| synonym | "IKK-2" RELATED [EC:2.7.11.10]
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| synonym | "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10]
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| synonym | "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10]
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| synonym | "STK12" RELATED [EC:2.7.11.10]
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| synonym | "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10]
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| synonym | "TBK1" RELATED [EC:2.7.11.10]
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| xref | EC:2.7.11.10
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| xref | MetaCyc:2.7.11.10-RXN
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| xref | Reactome:24217 "IkappaB kinase activity"
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| is_a | GO:0004674 ! protein serine/threonine kinase activity
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