| id | GO:0008534 Detailed information
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| name | oxidized purine base lesion DNA N-glycosylase activity
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| namespace | molecular_function
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| alt_id | GO:0003907
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| def | "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
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| comment | Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
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| subset | gosubset_prok
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| synonym | "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23]
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| synonym | "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23]
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| synonym | "8-oxoguanine DNA glycosylase activity" BROAD []
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| synonym | "bifunctional DNA glycosylase activity" BROAD []
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| synonym | "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23]
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| synonym | "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23]
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| synonym | "DNA glycosylase/AP-lyase activity" BROAD []
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| synonym | "DNA glycosylase/beta-lyase activity" BROAD []
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| synonym | "DNA-formamidopyrimidine glycosylase activity" EXACT []
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| synonym | "fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23]
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| synonym | "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23]
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| synonym | "formamidopyrimidine-DNA glycosylase activity" EXACT []
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| synonym | "Fpg protein" RELATED [EC:3.2.2.23]
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| synonym | "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
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| xref | EC:3.2.2.23
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| xref | MetaCyc:3.2.2.23-RXN
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| xref | Reactome:24932 "oxidized purine base lesion DNA N-glycosylase activity"
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| is_a | GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
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| is_a | GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity
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