| id | GO:0008633 Detailed information
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| name | activation of pro-apoptotic gene products
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| namespace | biological_process
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| def | "The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah]
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| synonym | "induction of pro-apoptotic gene products" RELATED []
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| xref | Reactome:111446 "Activation of BIM and translocation to mitochondria"
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| xref | Reactome:111447 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:111448 "Activation of NOXA and translocation to mitochondria"
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| xref | Reactome:111452 "Activation and oligomerization of BAK protein"
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| xref | Reactome:114294 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:114452 "Activation of BH3-only proteins"
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| xref | Reactome:1231885 "Granzyme-B activates BID by cleavage"
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| xref | Reactome:1231887 "tBID activates BAK protein"
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| xref | Reactome:1231895 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1253015 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1253219 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1253221 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1253248 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1253249 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:1253250 "Activation of BH3-only proteins"
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| xref | Reactome:1253251 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1253252 "Activation of PUMA and translocation to mitochondria"
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| xref | Reactome:1253253 "Activation of BIM and translocation to mitochondria"
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| xref | Reactome:1259613 "Granzyme-B activates BID by cleavage"
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| xref | Reactome:1259615 "tBID activates BAK protein"
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| xref | Reactome:1259625 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1280153 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1280155 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1280184 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1280185 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:1280186 "Activation of BH3-only proteins"
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| xref | Reactome:1280187 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1280188 "Activation of PUMA and translocation to mitochondria"
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| xref | Reactome:1280189 "Activation of BIM and translocation to mitochondria"
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| xref | Reactome:1280190 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1285006 "Granzyme-B activates BID by cleavage"
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| xref | Reactome:1285008 "tBID activates BAK protein"
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| xref | Reactome:1285018 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1299028 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1299030 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1299057 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1299058 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:1299059 "Activation of BH3-only proteins"
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| xref | Reactome:1299060 "Activation of BIM and translocation to mitochondria"
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| xref | Reactome:1299061 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1305577 "Granzyme-B activates BID by cleavage"
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| xref | Reactome:1305579 "tBID activates BAK protein"
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| xref | Reactome:1305587 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1326519 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1326730 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1326731 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1326761 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1326762 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:1326763 "Activation of BH3-only proteins"
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| xref | Reactome:1326764 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1326765 "Activation of BIM and translocation to mitochondria"
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| xref | Reactome:1333143 "Granzyme-B activates BID by cleavage"
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| xref | Reactome:1333145 "tBID activates BAK protein"
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| xref | Reactome:1333153 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1352626 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1352836 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1352838 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1352865 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1352866 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:1352867 "Activation of BH3-only proteins"
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| xref | Reactome:1352868 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1352869 "Activation of BIM and translocation to mitochondria"
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| xref | Reactome:1357574 "tBID activates BAK protein"
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| xref | Reactome:1357577 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1372854 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1373050 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1373073 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1373074 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1373075 "Activation of BH3-only proteins"
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| xref | Reactome:1378579 "tBID activates BAK protein"
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| xref | Reactome:1378582 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:1392867 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1393065 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1393066 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1393089 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1393090 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1393091 "Activation of BH3-only proteins"
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| xref | Reactome:139893 "Granzyme-B activates BID by cleavage"
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| xref | Reactome:139895 "tBID activates BAK protein"
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| xref | Reactome:139898 "Caspase-8 activates BID by cleavage"
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| xref | Reactome:139910 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1399130 "tBID activates BAK protein"
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| xref | Reactome:139915 "Activation of PUMA and translocation to mitochondria"
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| xref | Reactome:140534 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1417545 "Activation and oligomerization of BAK protein"
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| xref | Reactome:1417546 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1417574 "Activation of BMF and translocation to mitochondria"
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| xref | Reactome:1417575 "Activation of BH3-only proteins"
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| xref | Reactome:1417576 "Activation, myristolyation of BID and translocation to mitochondria"
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| xref | Reactome:1450434 "Caspase-8 is formed from procaspase-8"
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| xref | Reactome:1450639 "Activation, translocation and oligomerization of BAX"
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| xref | Reactome:1450666 "Activation of BAD and translocation to mitochondria"
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| xref | Reactome:1450667 "Activation of BH3-only proteins"
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| xref | Reactome:75108 "Activation, myristolyation of BID and translocation to mitochondria"
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| is_a | GO:0043065 ! positive regulation of apoptosis
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| relationship | part_of GO:0006915 ! apoptosis
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