id | GO:0016246   Detailed information |
---|---|
  name | RNA interference |
  namespace | biological_process |
  def | "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] |
  comment | Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. |
  synonym | "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah] |
  synonym | "RNAi" EXACT [] |
  xref | Wikipedia:RNA_interference |
  is_a | GO:0035194 ! posttranscriptional gene silencing by RNA |
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