| id | GO:0050983 Detailed information
|
|---|
| name | spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
|
|---|
| namespace | biological_process
|
|---|
| def | "The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN]
|
|---|
| comment | Note that this reaction is catalyzed by a single enzyme but since it has multiple steps, it appears in the process ontology.
|
|---|
| subset | gosubset_prok
|
|---|
| synonym | "(4-aminobutyl)lysine synthase activity" RELATED [EC:2.5.1.46]
|
|---|
| synonym | "[eIF-5A]-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46]
|
|---|
| synonym | "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT []
|
|---|
| synonym | "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT []
|
|---|
| xref | EC:2.5.1.46
|
|---|
| xref | MetaCyc:2.5.1.46-RXN
|
|---|
| is_a | GO:0046203 ! spermidine catabolic process
|
|---|