id | GO:0060070   Detailed information |
---|---|
  name | canonical Wnt receptor signaling pathway |
  namespace | biological_process |
  def | "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] |
  synonym | "canonical Wnt signaling pathway" EXACT [] |
  synonym | "frizzled-1 receptor signaling pathway" NARROW [] |
  synonym | "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] |
  synonym | "Wnt receptor signaling pathway via beta-catenin" EXACT [] |
  synonym | "Wnt receptor signalling pathway through beta-catenin" EXACT [] |
  is_a | GO:0016055 ! Wnt receptor signaling pathway |
  DPGLEAN01057
  DPGLEAN02104
  DPGLEAN06640
  DPGLEAN07088
  DPGLEAN11950
  DPGLEAN12819
  DPGLEAN18824
  DPGLEAN19669
  DPGLEAN22461