| id | GO:0070371 Detailed information
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| name | ERK1 and ERK2 cascade
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| namespace | biological_process
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| def | "A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases." [GOC:add, ISBN:0121245462, ISBN:0896039986]
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| comment | Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
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| synonym | "ERK cascade" BROAD [GOC:add]
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| synonym | "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
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| synonym | "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
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| synonym | "ERK1 cascade" NARROW [GOC:add]
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| synonym | "ERK1/2 cascade" EXACT [GOC:add]
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| synonym | "ERK2 cascade" NARROW [GOC:add]
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| synonym | "MAPK1 cascade" NARROW [GOC:add]
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| synonym | "MAPK3 cascade" NARROW [GOC:add]
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| xref | Reactome:112411 "ERK2 activation"
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| xref | Reactome:1253161 "ERK2 activation"
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| xref | Reactome:1280095 "ERK2 activation"
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| xref | Reactome:1298944 "ERK2 activation"
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| xref | Reactome:1326666 "ERK2 activation"
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| xref | Reactome:1352778 "ERK2 activation"
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| xref | Reactome:1372967 "ERK2 activation"
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| xref | Reactome:1392983 "ERK2 activation"
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| xref | Reactome:1417463 "ERK2 activation"
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| xref | Reactome:1450578 "ERK2 activation"
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| xref | Reactome:1471085 "ERK2 activation"
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| xref | Reactome:1483101 "ERK2 activation"
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| xref | Reactome:1526824 "ERK2 activation"
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| xref | Reactome:1532550 "ERK2 activation"
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| xref | Reactome:451478 "ERK activation"
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| xref | Reactome:451533 "ERK2 activation"
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| is_a | GO:0000165 ! MAPKKK cascade
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