id | GO:0070578   Detailed information |
---|---|
  name | RISC-loading complex |
  namespace | cellular_component |
  def | "A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP." [GOC:ab, PMID:18178619] |
  synonym | "microRNA loading complex" EXACT [GOC:ab] |
  synonym | "miRLC" EXACT [GOC:ab] |
  synonym | "RLC" RELATED [GOC:ab, GOC:mah] |
  is_a | GO:0030529 ! ribonucleoprotein complex |
  created_by | midori |
  creation_date | 2009-04-22T01:40:19Z |
  DPGLEAN04364
  DPGLEAN22568