| New model in OGS2.0 | DPOGS209357 |
|---|---|
| Genomic Position | scaffold151:+ 6235-18855 |
| See gene structure | |
| CDS Length | 5403 |
| Paired RNAseq reads | 9373 |
| Single RNAseq reads | 22545 |
| Migratory profiles | Query via corresponding ESTs |
| Best Bmobyx hit | BGIBMGA005686 (2e-17) |
| Best Drosophila hit | gigas (1e-66) |
| Best Human hit | tuberin isoform 5 (7e-77) |
| Best NR hit (blastp) | PREDICTED: similar to tuberous sclerosis 2 isoform 3 [Apis mellifera] (0.0) |
| Best NR hit (blastx) | tuberin, putative [Pediculus humanus corporis] (3e-101) |
| GeneOntology terms | GO:0046626 regulation of insulin receptor signaling pathway GO:0043547 positive regulation of GTPase activity GO:0032007 negative regulation of TOR signaling cascade GO:0043407 negative regulation of MAP kinase activity GO:0071109 superior temporal gyrus development GO:0033596 TSC1-TSC2 complex GO:0005096 GTPase activator activity GO:0048471 perinuclear region of cytoplasm GO:0008285 negative regulation of cell proliferation GO:0006897 endocytosis GO:0005829 cytosol GO:0006953 acute-phase response GO:0045792 negative regulation of cell size GO:0016020 membrane GO:0005634 nucleus GO:0005737 cytoplasm GO:0001843 neural tube closure GO:0032956 regulation of actin cytoskeleton organization GO:0046982 protein heterodimerization activity GO:0051492 regulation of stress fiber assembly GO:0005794 Golgi apparatus GO:0030100 regulation of endocytosis GO:0051898 negative regulation of protein kinase B signaling cascade GO:0030178 negative regulation of Wnt receptor signaling pathway GO:0030425 dendrite GO:0043025 neuronal cell body GO:0051726 regulation of cell cycle GO:0042803 protein homodimerization activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0051056 regulation of small GTPase mediated signal transduction GO:0005515 protein binding GO:0005792 microsome GO:0030030 cell projection organization GO:0045184 establishment of protein localization GO:0050680 negative regulation of epithelial cell proliferation GO:0051893 regulation of focal adhesion assembly GO:0006606 protein import into nucleus GO:0006469 negative regulation of protein kinase activity GO:0014067 negative regulation of phosphoinositide 3-kinase cascade GO:0005901 caveola GO:0007165 signal transduction GO:0030426 growth cone GO:0007507 heart development GO:0008104 protein localization GO:0050918 positive chemotaxis GO:0051260 protein homooligomerization GO:0021987 cerebral cortex development GO:0043491 protein kinase B signaling cascade GO:0005624 membrane fraction GO:0005622 intracellular GO:0016192 vesicle-mediated transport GO:0044430 cytoskeletal part GO:0051291 protein heterooligomerization |
| InterPro families | IPR016024 Armadillo-type fold IPR000331 Rap/ran-GAP IPR011989 Armadillo-like helical IPR018515 Tuberin-type domain IPR003913 Tuberin |
| Orthology group | MCL13813 |
Nucleotide sequence:
ATGGGCTCCAGAGATAGGGACACAAAGTCCTTTCATGACAAGTTGAAAGTGTTCTTCAAG
AAGGGAGCATCGGCGCCCGTCGCCGCACAGAACGAGCTGTTGGTGACGGCGGAGCTGCGC
CGGGAGCTGAGCCCCGAGACCCCACTCGGCCGCCGCTTGCGGGCCATCAAGGAGGTCGGC
GACCGAGTCCTACACATCAGAGTGCAAGAAGGTGGAATCGAGAAAATATGGAGTTGCACT
CGTGACCTCCTCGAGGACTCCAATATGGAAGCTCGTCACACAGTTCTTGCACTGTTGAAG
AACATAGCAGAGGGACAGACGGACATGCTGGTCATGAGAACTGTGCTGTTTAGGTTCCTA
AGAGAGACACACACCAGCCACCCAGCTGATGATTATGTGCTGCGATTCAAACTACTTTAC
TCACTCACCAACACGGGCAAGGACATTAAATGTTTTGAAGAAGAGATCGGTCCTTTCATA
TTGGAGTGGTTGCCTCGGATCCAGAATCCGTCACACATCATAGACTTTGTGAACCTCGTC
ATTAATGTGGTCAAGTTCAATGCCGTTTACTTGGATGAGGAAATTGTACATGGAATAGTC
AATAACGCGTGTCACCTGTGCGTGTACTCTTCGGAGGGCGGTGTGGTCCAGAGCTGCCTC
ACTCTACTGCAGGCCGTCGTCTCGTACTCGTTGCTGCCTCGCGCCGCGTTGCCGACCTTC
GTGGCCGCACTCTGCCGCACCGTCAACATCGAACATTACTGCCAGAATAGCTGGAAGCTA
ATGCGGAACGTGGTGGGCGCGGACATGGGACACGCGGCGCTGCAGGAGATGGTGGAACTG
GTGCGTGGGGCGGGGGGCGGTGAGGGGTGCGGGGAGGACGCGGCCGGCCTGGCGCGAGGA
GCTGTGTTCTATATAAACATGGCGCTGTGGGGGCCGCGGCGCGTGCACACCCTGCATGTA
TCGTTCCTAGCGGTGCTGCCCGCCTTCCTGAAGGCTCTGGCCGGCCGTCACTCGGTGGTC
ACGTATGAGGTGGTGATGGCGCTCCAGAGCCTGGTCACCCGCGTGCACGAACAATTGCAC
GCCGTCGCCTGGGACCTCGTTCTGGACATCGTAAGGGCTGTACTGCAGCAGGACAAGAGT
CTGGACCCTCCCAACGAACTGATCCACACGCGCGTCCACGCTCTGATAACATCCATAGAG
TCGTTACACGAGGCGGGTCAGTTCCAGGGGGACGTGGAGGCGCTCCTGGACCTCATCGAC
CTCTGCGGACACGACCGCCCGGAGTCGTCTGTGATGCGTCTGATCTCCGAACGCTGCCTG
TACATGGGCGGATCCGCGGCGGGCTCCGCGCTGCAGCTGGCCGAGCGCTACGTCCGCCTG
GAGCCTCGCCCCGCGGTCAGGCTGCACGCCCTCGCCTCGCTAGTGGCTTACATCAAGAGA
CACCGATGTACCCACGGCGAAGAGTTGTCGGAGCGTGTGGGCGGGTCGATAGCGGCGACC
TGCGCCCTGGACGCCGACGTGTCCATCAGGGCCGCCATCGCCAAGGCCATACCGGAACTG
GCCAGGCTGTGCTCGCCGGACGCCTGCATCGACCTCATCGACCAGCTGGAGAAGATCTTG
AACCGTCCCTTCGACATGTACGTGACTGAGGTGTCGATCCCCGGAGACGCCGACACTTCC
GACCTGCAGGCGGCCGCCGCGGCCCTGCTGGAACTCCTCCACGACAAGCTGTTGCGAGCC
CCGGCCGCGCCCGCCGCCCGCGCCTTCCTCGTACTGCTGGACCACCTCGACCACCACTAC
CGCCGCCCAGCGCTGCTCCACCACCACCCTGACATACGACTGAAGATCTTCGACATGCTG
TTCGCTCTGCGTGCCAACGAGTTCAACTGCGTGGGCTTCTGCTACGACGCCGCAGGGTGT
GCGGTGTCAGGGGCGGGGGCGCTCCGTCTCCGCGCGCGCTGTTCTCCTCTGCTGCTAGTG
GAGCCCCCCGCACCCCGCGCCGCACCCCCGCCCGGTCCCCGGGAGCTGCCCCCCGGCGCC
GTCCTGCTGCCGGCCGGTCGATTAGCGCGCGCCCTGCCCGCCGCGCTGGCTCGCGAACCT
GAGTGGCCGGTGTTGGCTCACGTACTGCGCGCTCTGCCACCACTGCTGCACGCGCGTGCC
CTCGCCCTGGGTCGGCGAGCTCAGGACCTGGATCTGCTGGCGGCGACCCTTTGCTCGATG
GTGTCCGACCGTAGCCTGTCAGGTGCCGGCGGAGGCCGGCCGCTCGTGTCGGACTTCCAC
GCGGCGGCGCTGCCGTCGCTGGCGGCGCTCGCCTCCTATCACGCCTACCTGGAGCCGCAG
ACACAACAGCGTATCGTCAAGTGTCTGCTCAAATACGGGATGGTGCTCCGAGCGCCGCAG
CCCTACATTAACGCTCTCACCATGTTCACCCTGGAGACCCGGGACACGATGGTCAAACTG
CTCCCGGAGGTGCTGCTGGACCTGTCCAAGATCTCCGACACCAAGGCCATCGCTAGCCCC
ATGCTGGAGTTTCTTTCCACCCTGACCCGGCTGCCCCGCGTGTACGCTTCGTTCGTGGAG
GACCAGTGTATGACGGTGTTCGCCATCCTCCTGCCGTACACGAACCCGTCTCGCTACAAC
CACTACGTAGTGTCTCTGGCTCACCACGTGATCGCCGCCTGGTTCCTCAAGTGTCGCCTC
TCCTACAGACGGAACTTCGTCAGCTTCATCATTAACGGCCTTCACAACTACATCATAGTG
CCGTTCGAGGAACAGTACGCGCACAGAGCACAGAGGAACGAGGACTCCTCCAACAGACAG
AGGAGCTCCAGCCTGGGCTCCCGCGCAGTGTCTCACGCCCCTCTGTCGGGTCGGGGGAGC
TCAGCGCGGGACTCGGCCGCCCTAGCCGCCTTCCACGTGGAGCTGACCGAGACCTGCATC
GACCTCCTAGCACGGTACACCTTCACACCGTGTAGCGTCAAGCCGCAGAGGAGCGACACG
GCCGAGTTCCTGTTCAGCGGTGGGCAGTCCACCACGTGGCTGGTGGGACACAAGCTGGTC
ACCATCACCACCTCCGGCTGTCTACAGAACTCTATCAAGCAGGGATTGTGCGAGAGGTGC
GCTACACTGTGTCGCCGACACGCGGAGAGTGCCAGCAGCGCCCTGCCCGGGGACACGCCG
CAGGATAACTCCGACCAGTCCGGGGCCCTCCAGCCGCCGCCGTCTGACATCAAACGGCAA
AACTCGGCTGAGAACAAAACCGCGGATCCTCTCCTGGACGCCCTCAATCAATTCACGCAA
CGTTTCGAGAAAGTGTCCAAAGAAGTCGAGTGCGAGGAGGGCGGCTGGTCCCGAGTGGGA
GAGCTGACGGCGGGCGGCACCTGCCCGTGCTGGTGCGCGCGGTGGGCGGAGCTCCACGTC
CGCTCACCCACCGGAGACGTCTCCTGGCTGCTGAGGATGCAGAATCATATCAGCTCGTCG
CAGCTCCAGGAGTGGCCGCTGCAGGACGTGCTGGCCCTCCTGGCGCCGCCGGGGGCTTCG
GTCCTGTGTCAGCCGGCCGGCCCCGCCCCCGCCACGCCCCCGCCCCGCCGCCGGCCCCCA
CCGAAAATTCCACTCGTCCGTCTCGATCCTCTTTACAACGTTCTCACGCACAGGACCTGC
ACAAATCAAGCATGTTCCAGTTCTGATTCGGTGGTGGGTGACCGCCGCAGCCAGTCGGGG
GGCGCGGCGGGCGGTGCTCGCCTCAGCACGCAGCCCATCAACATCCCGGGCTCCCCTCAG
AGACAGAGCTCGTCCAGCACCACGGACGACGAGGAGATGCTGCTCACGCGGCCGGAGGGT
AAATCTCGTCATCACGTGCGTCGCTCCAACTCGTCCCCGGAGATGTCATCTCTGAAGGGT
CTGTCGCGGGAGCACGAGCACGACTTCACCGACCCCGACGAACACATCCTGCTGCCCATG
TGTGAACCGGCGAACCCGGTGTCTCTACACGCGCCGAAGAAGGCTCCCAAGAAAACGGAC
ACTCGCGTGTCATGTGAGGCCATACCGGAGGAGATGAGCGGCACCTCGCCGCAGCCTCAC
CCTCACCCTCAGCACCCTCAACACCCTCAGCACCCACAGCAGACGCAACACCCGCACCCT
CACCCTCACCTCGTCACATACAACTCGGACCCGGGAGCGGGCGAGGAGCCGCGACCCTCC
GCGCACCAGCTGCAGAAGACGAGCAGCGACAGTCGCGTTACTCTCAGCTCCACCGAGGGT
CGCGGAGTGGGAGCAGGGGTCGCGGGCGGCGGGGGGCTGGGGCCGGGAGCGGGGGCGGAG
CACCGGGACGGGCGGGACGAGCTGCAGCCCCTCGCCCGATCCAAGAGATCCAACACTATC
AGCGTCATGAGCCCCACGAGGAGGAACCGTGAGTCTCCTCGCTCCGCGTCCAGCACACCC
AGCTCTGCGGGCGGGTCCGGGGCGGGAGGAGGTGCGGGCGGAGTGTCTCCGTCGTTCGTG
TTCCTGCAGCTGTACCACAACATGAGCACGTTTCCGATCTCGCCTTGCGTGCCCGGGTCT
CCTCCCCCGCCGCTGGTGTGTGGCGGCGCGCTTCACGCTCGACCGCTCAAAGTGTCGGAC
GCTCAGCATCAGAGGACCATCAAGAACCTGGACCTCGTGCCGCCGCTCGAGACCTACAAG
GTGGGCGTGCTGTACGTGGGCCCCGGACAGCAGGACGACGAGGTGGCTATACTCAAGAAC
GAATACGGCAGCGTCAGGTACATGGAGTTCCTGCGTCAGCTGGGCACGCTGGTGCCTCTG
GAGGGCGCCGAGGAGCCCAACCTGTTCCTGAACCTCGAGAAGGGCGGCAAGGACGGCCGG
TACACGTACGTGTGGAGCGACGACATCATGCAAGTGTTGTTCCACGTGGCCACCGCCATG
CCCAGCTCCGACAGGGACCCCACCTGCAACGAGAAGAGGAAGTACATCGGAAACGACTTC
GTCAGCATCGTCTACAACGACTCGCAGCACAACTTCAATATACACACCATCAAGGGTCAG
TTCAACCTGTGCATCGTGGTGGTGGAGCCGCTCGCTCACGGCATGCATCGCGTCACCTTG
AAGAGTAAGGACGAGAGACTCCGCAGCGAGTTCCTAGCACACGCCGAGCCCGCCTGCGTG
TCCGACCACAACGTGGCGCTGCTAGCGAGACAACACGCCCTGCACGCCGCGCTGGCCTCT
CAGATCTCCCAGTCCCTGAAGCCGGGCGGCGAGCCGTACGCGTCCAACTCCCTGGAGCGC
CTGAGGGTCATCAAACGCCTGCGGGCCCGAGCGCTGGCCGCCCGCCTGGCTCGGCCCGCG
CCGCCCTACGCCCCGCCCGACCCTGCGCCCCTCGCCATCGACGACTTCAACCACTACACG
TGA
Protein sequence:
MGSRDRDTKSFHDKLKVFFKKGASAPVAAQNELLVTAELRRELSPETPLGRRLRAIKEVG
DRVLHIRVQEGGIEKIWSCTRDLLEDSNMEARHTVLALLKNIAEGQTDMLVMRTVLFRFL
RETHTSHPADDYVLRFKLLYSLTNTGKDIKCFEEEIGPFILEWLPRIQNPSHIIDFVNLV
INVVKFNAVYLDEEIVHGIVNNACHLCVYSSEGGVVQSCLTLLQAVVSYSLLPRAALPTF
VAALCRTVNIEHYCQNSWKLMRNVVGADMGHAALQEMVELVRGAGGGEGCGEDAAGLARG
AVFYINMALWGPRRVHTLHVSFLAVLPAFLKALAGRHSVVTYEVVMALQSLVTRVHEQLH
AVAWDLVLDIVRAVLQQDKSLDPPNELIHTRVHALITSIESLHEAGQFQGDVEALLDLID
LCGHDRPESSVMRLISERCLYMGGSAAGSALQLAERYVRLEPRPAVRLHALASLVAYIKR
HRCTHGEELSERVGGSIAATCALDADVSIRAAIAKAIPELARLCSPDACIDLIDQLEKIL
NRPFDMYVTEVSIPGDADTSDLQAAAAALLELLHDKLLRAPAAPAARAFLVLLDHLDHHY
RRPALLHHHPDIRLKIFDMLFALRANEFNCVGFCYDAAGCAVSGAGALRLRARCSPLLLV
EPPAPRAAPPPGPRELPPGAVLLPAGRLARALPAALAREPEWPVLAHVLRALPPLLHARA
LALGRRAQDLDLLAATLCSMVSDRSLSGAGGGRPLVSDFHAAALPSLAALASYHAYLEPQ
TQQRIVKCLLKYGMVLRAPQPYINALTMFTLETRDTMVKLLPEVLLDLSKISDTKAIASP
MLEFLSTLTRLPRVYASFVEDQCMTVFAILLPYTNPSRYNHYVVSLAHHVIAAWFLKCRL
SYRRNFVSFIINGLHNYIIVPFEEQYAHRAQRNEDSSNRQRSSSLGSRAVSHAPLSGRGS
SARDSAALAAFHVELTETCIDLLARYTFTPCSVKPQRSDTAEFLFSGGQSTTWLVGHKLV
TITTSGCLQNSIKQGLCERCATLCRRHAESASSALPGDTPQDNSDQSGALQPPPSDIKRQ
NSAENKTADPLLDALNQFTQRFEKVSKEVECEEGGWSRVGELTAGGTCPCWCARWAELHV
RSPTGDVSWLLRMQNHISSSQLQEWPLQDVLALLAPPGASVLCQPAGPAPATPPPRRRPP
PKIPLVRLDPLYNVLTHRTCTNQACSSSDSVVGDRRSQSGGAAGGARLSTQPINIPGSPQ
RQSSSSTTDDEEMLLTRPEGKSRHHVRRSNSSPEMSSLKGLSREHEHDFTDPDEHILLPM
CEPANPVSLHAPKKAPKKTDTRVSCEAIPEEMSGTSPQPHPHPQHPQHPQHPQQTQHPHP
HPHLVTYNSDPGAGEEPRPSAHQLQKTSSDSRVTLSSTEGRGVGAGVAGGGGLGPGAGAE
HRDGRDELQPLARSKRSNTISVMSPTRRNRESPRSASSTPSSAGGSGAGGGAGGVSPSFV
FLQLYHNMSTFPISPCVPGSPPPPLVCGGALHARPLKVSDAQHQRTIKNLDLVPPLETYK
VGVLYVGPGQQDDEVAILKNEYGSVRYMEFLRQLGTLVPLEGAEEPNLFLNLEKGGKDGR
YTYVWSDDIMQVLFHVATAMPSSDRDPTCNEKRKYIGNDFVSIVYNDSQHNFNIHTIKGQ
FNLCIVVVEPLAHGMHRVTLKSKDERLRSEFLAHAEPACVSDHNVALLARQHALHAALAS
QISQSLKPGGEPYASNSLERLRVIKRLRARALAARLARPAPPYAPPDPAPLAIDDFNHYT