| New model in OGS2.0 | DPOGS202258 |
|---|---|
| Genomic Position | scaffold2345:+ 4748-9092 |
| See gene structure | |
| CDS Length | 1371 |
| Paired RNAseq reads | 1292 |
| Single RNAseq reads | 3451 |
| Migratory profiles | Query via corresponding ESTs |
| Best Bmobyx hit | BGIBMGA004909 (6e-161) |
| Best Drosophila hit | presenilin, isoform C (8e-116) |
| Best Human hit | presenilin-1 isoform I-463 (3e-97) |
| Best NR hit (blastp) | PREDICTED: similar to Presenilin CG18803-PB isoform 1 [Tribolium castaneum] (9e-154) |
| Best NR hit (blastx) | PREDICTED: similar to presenilin [Strongylocentrotus purpuratus] (2e-106) |
| GeneOntology terms | GO:0005640 nuclear outer membrane GO:0005886 plasma membrane GO:0006486 protein amino acid glycosylation GO:0006914 autophagy GO:0006979 response to oxidative stress GO:0016080 synaptic vesicle targeting GO:0021904 dorsal/ventral neural tube patterning GO:0048167 regulation of synaptic plasticity GO:0048705 skeletal system morphogenesis GO:0050435 beta-amyloid metabolic process GO:0005739 mitochondrion GO:0016485 protein processing GO:0042325 regulation of phosphorylation GO:0004175 endopeptidase activity GO:0005634 nucleus GO:0008013 beta-catenin binding GO:0016337 cell-cell adhesion GO:0051605 protein maturation by peptide bond cleavage GO:0009986 cell surface GO:0008233 peptidase activity GO:0005794 Golgi apparatus GO:0043085 positive regulation of catalytic activity GO:0023034 intracellular signaling pathway GO:0050852 T cell receptor signaling pathway GO:0051966 regulation of synaptic transmission, glutamatergic GO:0000139 Golgi membrane GO:0005789 endoplasmic reticulum membrane GO:0001568 blood vessel development GO:0001756 somitogenesis GO:0002244 hemopoietic progenitor cell differentiation GO:0007219 Notch signaling pathway GO:0015031 protein transport GO:0042987 amyloid precursor protein catabolic process GO:0048538 thymus development GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis GO:0005887 integral to plasma membrane GO:0005783 endoplasmic reticulum GO:0001764 neuron migration GO:0002286 T cell activation involved in immune response GO:0006469 negative regulation of protein kinase activity GO:0006974 response to DNA damage stimulus GO:0007220 Notch receptor processing GO:0007507 heart development GO:0009790 embryo development GO:0009791 post-embryonic development GO:0015813 L-glutamate transport GO:0030165 PDZ domain binding GO:0030326 embryonic limb morphogenesis GO:0043025 neuronal cell body GO:0043065 positive regulation of apoptosis GO:0043406 positive regulation of MAP kinase activity GO:0050673 epithelial cell proliferation GO:0000186 activation of MAPKK activity GO:0001933 negative regulation of protein amino acid phosphorylation GO:0015871 choline transport GO:0040011 locomotion GO:0048854 brain morphogenesis GO:0050820 positive regulation of coagulation GO:0006509 membrane protein ectodomain proteolysis GO:0001708 cell fate specification GO:0005622 intracellular GO:0007613 memory GO:0030424 axon GO:0042640 anagen GO:0043198 dendritic shaft GO:0060075 regulation of resting membrane potential GO:0000045 autophagic vacuole assembly GO:0001934 positive regulation of protein amino acid phosphorylation GO:0002573 myeloid leukocyte differentiation GO:0007176 regulation of epidermal growth factor receptor activity GO:0022008 neurogenesis GO:0030426 growth cone GO:0030900 forebrain development GO:0035253 ciliary rootlet GO:0043227 membrane-bounded organelle GO:0043393 regulation of protein binding GO:0045296 cadherin binding GO:0050771 negative regulation of axonogenesis GO:0005624 membrane fraction GO:0006839 mitochondrial transport GO:0021795 cerebral cortex cell migration GO:0021870 Cajal-Retzius cell differentiation GO:0031410 cytoplasmic vesicle GO:0048666 neuron development GO:0051402 neuron apoptosis GO:0001947 heart looping |
| InterPro families | IPR006639 Peptidase A22, presenilin signal peptide IPR001108 Peptidase A22A, presenilin |
| Orthology group | MCL11917 |
Nucleotide sequence:
ATGAGTGACACCGGTAGTGATATAGAAGCGACTGAGCATACTGCACTCATGGACGGACAT
ATAGCTGAGGCCCGCCCAGACAGGGAAGTTGCTGAACGCATCGCGAGAAAACGTAAAACA
AAGTCGGATACAACCCGTAACTATGGAACAGTGGAACAGCCAGATAGTAGGCAGACAGGC
GCAGGAAGCTCCCGTCGGAATCCCTCGGAGGAAACGGCAGACCAGAGCGAAGAAATGGAG
TTGAAATATGGTGCGCGACATGTCATTAAACTGTTTGTGCCAGTAACCTTGTGCATGATG
GTAGTCGTCGCCACTATATCATCCATTACTTTTTACTCCGTGAAAGATGTCTACTTGGCA
TATACTCCGTTCCATGAGGAGAGTCCTCACGCTGCGACGAAAGTGTGGAATGCTCTCGCA
AATTCAATGATCCTGCTGTGTGTGATAGCTTTTATGACGGTGTTGCTTATAGTACTGTAC
AAGAAACGCTGCTACAAGGTCATCCATGGCTGGTTGATACTGTCTTCGCTGATGCTACTT
TTCTTGTTCTCATATCTGTATATAGAGGAAGCGCTGCGAGCTTATAACATCCCACTGGAT
TATATAACGATATTTTTTGTGATGTGGAACTTTGGTGTGATGGGAATGATCACCATTCAC
TGGAAGGGTCCGCTGCGAATGCAGCAGGCGTACCTCATATTTATAGCGGCATTGATGGCA
CTGGTTTTTATTAAATATCTGCCGGAATGGACAACATGGGCTGTCCTAGCTGTTATATCA
ATTTGGGATTTGATAGCCGTCCTCACACCAAAAGGACCTCTGAGGATACTCGTTGAGACG
GCTCAGGAGAGAAATGAACCGATATTCCCAGCACTTATTTATTCATCGACGGTGATGTAC
ATGCTGGCAGCGGTCGAAGGATCTTCGAACTCGGAGGGTAACGTTAACTCCGGGGGAGAT
GGTGACGGTGAGGGAGGTTTTGATAACGCTTGGAGGGAGCGCGCCGCAGCCGGAGCCCCG
AGACACTTACGAGTGGAGGGTACAGCATCAGCGAGATACGTCACCAGGGTTGAGGAGCCG
TCGCAGGATGCTGATGACGAGAAGGGCGTGAAATTAGGTCTGGGCGATTTCATCTTTTAC
AGCGTTCTGGTTGGTAAGGCCAGCTCGTACGGCGACTGGAACACCACACTCGCTTGTTTC
ATGGCCATACTTATTGGTCTGTGTCTCACACTGTTGTTGCTGGCTATATTCAAGAAGGCG
TTGCCCGCTCTGCCAATATCAATAACTTTCGGACTCATTTTTTACTTCGCGACCCGATCC
ATAGCAAAACCGTTCGCGGACGCGCTCGCCGCTGACCAAGTTTTCATTTAG
Protein sequence:
MSDTGSDIEATEHTALMDGHIAEARPDREVAERIARKRKTKSDTTRNYGTVEQPDSRQTG
AGSSRRNPSEETADQSEEMELKYGARHVIKLFVPVTLCMMVVVATISSITFYSVKDVYLA
YTPFHEESPHAATKVWNALANSMILLCVIAFMTVLLIVLYKKRCYKVIHGWLILSSLMLL
FLFSYLYIEEALRAYNIPLDYITIFFVMWNFGVMGMITIHWKGPLRMQQAYLIFIAALMA
LVFIKYLPEWTTWAVLAVISIWDLIAVLTPKGPLRILVETAQERNEPIFPALIYSSTVMY
MLAAVEGSSNSEGNVNSGGDGDGEGGFDNAWRERAAAGAPRHLRVEGTASARYVTRVEEP
SQDADDEKGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFMAILIGLCLTLLLLAIFKKA
LPALPISITFGLIFYFATRSIAKPFADALAADQVFI