| id | GO:0038084 Detailed information
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| name | vascular endothelial growth factor signaling pathway
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| namespace | biological_process
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| def | "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]
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| comment | In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
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| is_a | GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
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| is_a | GO:0035924 ! cellular response to vascular endothelial growth factor stimulus
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| created_by | rfoulger
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| creation_date | 2012-02-01T02:27:32Z
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