MonarchBase - Protein-coding gene

DPOGS210796
Transcript	DPOGS210796-TA	3084 bp
Protein	DPOGS210796-PA	1027 aa
Genomic position	DPSCF300027 - 1120442-1130020
RNAseq coverage	632x (Rank: top 20%)

Annotation
*Heliconius*	HMEL014180	85.30%
*Bombyx*	BGIBMGA007111-TA	80.85%
*Drosophila*	su(r)-PB	68.76%
EBI UniRef50	UniRef50_Q12882	63.87%	Dihydropyrimidine dehydrogenase [NADP+] n=142 Tax=root RepID=DPYD_HUMAN
NCBI RefSeq	XP_001648193.1	70.53%	dihydropyrimidine dehydrogenase [Aedes aegypti]
NCBI nr blastp	gi\|157103945	70.53%	dihydropyrimidine dehydrogenase [Aedes aegypti]
NCBI nr blastx	gi\|157103945	70.53%	dihydropyrimidine dehydrogenase [Aedes aegypti]

Group
Gene Ontology	GO:0008152	7.1e-80	metabolic process
	GO:0003824	7.1e-80	catalytic activity
	GO:0004158	9e-53	dihydroorotate oxidase activity
	GO:0055114	9e-53	oxidation-reduction process
	GO:0005737	9e-53	cytoplasm
	GO:0006207	9e-53	'de novo' pyrimidine base biosynthetic process
	GO:0004152	7.8e-37	dihydroorotate dehydrogenase activity
	GO:0006222	7.8e-37	UMP biosynthetic process
	GO:0051536	3.9e-35	iron-sulfur cluster binding
	GO:0016491	7.8e-35	oxidoreductase activity
KEGG pathway	ame:410207	0.0
	K00207 (E1.3.1.2, DPYD)	maps->	Pantothenate and CoA biosynthesis
			Drug metabolism - other enzymes
			Pyrimidine metabolism
			beta-Alanine metabolism
InterPro domain	[494-838] IPR013785	7.1e-80	Aldolase-type TIM barrel
	[529-834] IPR005720	9e-53	Dihydroorotate dehydrogenase, class 1
	[529-834] IPR012135	7.8e-37	Dihydroorotate dehydrogenase, class 1/ 2
	[3-197] IPR009051	3.9e-35	Alpha-helical ferredoxin
	[36-188] IPR012285	7.8e-35	Fumarate reductase, C-terminal
	[188-484] IPR023753	3.4e-08	Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
Orthology group	MCL12118		Single-copy universal gene

Nucleotide sequence:

>DPOGS210796-TA
ATGTCGAAGGTATTACTGAGTCGAGATCTGCCGGATATTGAGAACCTTCTTAAGCTTAACCCGACTGTTAAGCCATATACCAACCTGGTGCCATCAGCACAGACGAAGAAGAATAAACAGCACTGGAAAAGGAATGCCGATAGAAAATGCACTAGTTGTCCAAGTCTCGAGAGGAATTTCGATGACATCAAACACACGACATTGTCTGAGCGTGGTGCTTTGAAAGAGGCAGCTCGTTGTCTGAAATGTGCTGACGCGCCCTGTCAGAAGTCCTGCCCGACGCAGATCGACGTCAAAAGCTTTATAACAAGCATAGCTAATAAGGCAATGAACTATTATGGCGCCGCCAAAGAAATACTCTCAGACAACCCCTTGGGTCTCACTTGTGGAATGGTTTGCCCCACCAGTGACTTGTGCGTCGGCGGATGTAACTTACACGCGAGCGAAGAGGGCGCCATTAATATCGGTGGATTACAGCATTTCGCTGTTGAAACATTCATGAAAATGGGTATCTCCCAGACATTGGATCCAAAAACGAAACCCCTGCCTCGAGGTGATAAAAAAATTGCTCTTATAGGCGGCGGACCGGCAAGCTTGAGTTGTGCTTGTTTTTTGGCAAGGATGGGTTATAAGAATATTACGGTGTTTGAGAAAGAAAAATATCTTGGAGGACTAAGTTCATCAGAGATCCCACAGTACCGCCTTCCGTATGACGTGGTTCAATTCGAGATCGATCTCATCAGGGACCTTGGAGTGAAGTTCGTCACAGGAAGGAAACTTTCAACCAGTGACATAACTGTTAATGGACTTTTTAAAGATGGTTATGATGCTGTGTTTCTTGGCATCGGTCTGCCCGAGCCAAAGAGCATTCCTATCTTCGAAAACCTAACACCAGAAATGGGATTTTACACTAGCAAACAGTTTTTACCCCTGGTGTCCAGGGGCAGCAAAAGAGGCTTATGTAGCTGTTCGTCGTTGCCGGTTCTGTCTGGTACTGTGTTGGTTCTTGGGGCGGGAGACACGGCCTTCGACTGCGCCACATCAGCACTCCGCTGCGGCGCCAAGAAAGTGTTTGTCGTGTTCAGGAAAGGCATCACTCACATAAGAGCTGTTCCCGAGGAGGTTGATCTGGCTAAGGAAGAAAAATGTGAGTTCATACCATTTATGTCACCGCGAGAAGTAATCGTCAGAAACGGAAAGATAACTGCCTTAAAAATGTTCAGAACTGAACAATTAGATGATGGCGAATGGTTCGAAGACCCAGATCAAGTGTTGCAGCTGAAGGCCGACTTCATCATATCCGCGTTCGGATCTGGACTTTATGATGAAGACGTGAAACAGGCGATGGATGGCGTGAAATTAAATAGCTGGGGTCTTCCCGAAATAGATAATACTTGTATGCAGAGTTCGAGCAATCCGAAGGTGTTTGTTGGCGGGGACTTGGCCGGCGTCGCTGACACCACCGTGGAGTCCGTCAACGACGGAAAAACTGCCGCTTGGTACATGCATTGCTACCTACAGGGCATACCATTCTCAGCGGCCATTGAGCTGCCGAAATTCCATACAGACATCGATGAGGTGGATCTGTCAGTGGAGGTCTGCGGAATCCGGTTCGAGAATCCTTTCGGCCTAGCGAGCGCTCCGCCCACCACCAGCTCCGCCATGATAAGGAGAGCCTTCACCCAGGGCTGGGGCTTCGTGGTTACTAAGACCTTCGGACTTGATAAGGACATCGTTACGAACGTGTCACCGCGTATAGTACGCGGTGTGACCTCGGGAGAGAACTACGGACCCGGCCAAGGATCCTTCTTGAATATTGAGCTGATCTCCGAAAAATGTGAAGCTTACTGGTGTCAGAGTATCACGGAGCTAAAACGGGACTTCCCCACTAAGGTGATAATAGCGTCTATAATGTGTTCATACAACGAGGACGACTGGACGGAGCTGGCGAGGAAAGCCGAGGCGAGCGGAGCGGACGCGCTGGAGCTCAACCTGTCCTGCCCGCACGGCATGGGAGAGAGCGGGATGGGGCTAGCGTGCGGACAGGACCCGGTACTGGTGAAAGGAATATCCCAGTGGGTGCGGAAGGCTATAAACATACCGTTTTTCGTGAAGCTGACTCCCAACATCACAGACATAGTATCAATAGCGACGGCCGCTTATGAAGGCGGCGCTAGTGGTGTGTCTGCCATCAACACCGTGTCCGGTCTGATGACAGTTAGGGCGGATGCTACTCCGTGGCCTCAAGTCGGTCGCGAGAAAAGCACAACATACGGCGGTGTATCCGGCAACGCGACGCGGCCGATGGGATTGCGAGCTGTGTCCGCCATCGCTAACAAGTTACCGGGATTCCCCATACTCGGCATAGGAGGCATTGACTCCGCGGACTCAGCCTTGCAGTTCATGCTGTGCGGCGCACCAGTCGTTCAGATCTGTAGTGCGGTTCAAAACCAGGACTTCACCGTTGTTGAGGACTATGTGACAGGTCTTAAGGCGCTTTTATATTTACGATCGAGGGGTCTCCAAGGCTGGACGGGACAATCGCCGCCCACCAACAAACATCAGAAAGGGAAACCGGTGCAGACGATATGTGATGAAAACGGCAAGGTGTTAGCACACTTCGGTCCTTATATTAAGAAACGCGAAGGAGTACTTCACGAGCAACGTTTAAATACAAATATTTTGGCTGACAACACCACGGAATGTCCACGGAGGAATGTCAACGGCCATAATAAGGTGCCAAGGATCAGAGACGTCGTCGGTGAAGCGCTGAACAGGATCAGTTCATACAAAAAACTGGACAATACAAAACAAGTTGTAGCCTTGATAGACGATGATATGTGTATTAACTGTGGTAAATGTTACATGGCGTGCGCGGATTCAGGATACCAGGCTATTGAATTCGATGAACAAACGCACATACCTCGCGTCACTGAAGACTGTACCGGATGTACTTTGTGCCTTTCCGTTTGTCCCATCATCGACTGTATATCAATGGTTCCCAAGAAAATACCACACGTTATAAAACGGGGACTTCACTACGAGATACACCCTGTATCACCGTTGGACGGAGTTTGTCAATAA

Protein sequence:

>DPOGS210796-PA
MSKVLLSRDLPDIENLLKLNPTVKPYTNLVPSAQTKKNKQHWKRNADRKCTSCPSLERNFDDIKHTTLSERGALKEAARCLKCADAPCQKSCPTQIDVKSFITSIANKAMNYYGAAKEILSDNPLGLTCGMVCPTSDLCVGGCNLHASEEGAINIGGLQHFAVETFMKMGISQTLDPKTKPLPRGDKKIALIGGGPASLSCACFLARMGYKNITVFEKEKYLGGLSSSEIPQYRLPYDVVQFEIDLIRDLGVKFVTGRKLSTSDITVNGLFKDGYDAVFLGIGLPEPKSIPIFENLTPEMGFYTSKQFLPLVSRGSKRGLCSCSSLPVLSGTVLVLGAGDTAFDCATSALRCGAKKVFVVFRKGITHIRAVPEEVDLAKEEKCEFIPFMSPREVIVRNGKITALKMFRTEQLDDGEWFEDPDQVLQLKADFIISAFGSGLYDEDVKQAMDGVKLNSWGLPEIDNTCMQSSSNPKVFVGGDLAGVADTTVESVNDGKTAAWYMHCYLQGIPFSAAIELPKFHTDIDEVDLSVEVCGIRFENPFGLASAPPTTSSAMIRRAFTQGWGFVVTKTFGLDKDIVTNVSPRIVRGVTSGENYGPGQGSFLNIELISEKCEAYWCQSITELKRDFPTKVIIASIMCSYNEDDWTELARKAEASGADALELNLSCPHGMGESGMGLACGQDPVLVKGISQWVRKAINIPFFVKLTPNITDIVSIATAAYEGGASGVSAINTVSGLMTVRADATPWPQVGREKSTTYGGVSGNATRPMGLRAVSAIANKLPGFPILGIGGIDSADSALQFMLCGAPVVQICSAVQNQDFTVVEDYVTGLKALLYLRSRGLQGWTGQSPPTNKHQKGKPVQTICDENGKVLAHFGPYIKKREGVLHEQRLNTNILADNTTECPRRNVNGHNKVPRIRDVVGEALNRISSYKKLDNTKQVVALIDDDMCINCGKCYMACADSGYQAIEFDEQTHIPRVTEDCTGCTLCLSVCPIIDCISMVPKKIPHVIKRGLHYEIHPVSPLDGVCQ-

Monarch geneset OGS2.0

Nucleotide sequence:

Protein sequence: