id | GO:0003810   Detailed information |
---|---|
  name | protein-glutamine gamma-glutamyltransferase activity |
  namespace | molecular_function |
  def | "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] |
  subset | gosubset_prok |
  synonym | "factor XIIIa" RELATED [EC:2.3.2.13] |
  synonym | "fibrin stabilizing factor" RELATED [EC:2.3.2.13] |
  synonym | "fibrinoligase activity" EXACT [] |
  synonym | "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] |
  synonym | "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] |
  synonym | "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] |
  synonym | "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] |
  synonym | "TGase activity" EXACT [] |
  synonym | "tissue transglutaminase" NARROW [EC:2.3.2.13] |
  synonym | "transglutaminase activity" EXACT [] |
  xref | EC:2.3.2.13 |
  xref | MetaCyc:2.3.2.13-RXN |
  xref | Reactome:11549 "protein-glutamine gamma-glutamyltransferase activity" |
  xref | RESID:AA0124 |
  is_a | GO:0016755 ! transferase activity, transferring amino-acyl groups |
  DPGLEAN02025
  DPGLEAN02026
  DPGLEAN03897
  DPGLEAN17132
  DPGLEAN20347