| id | GO:0004362 Detailed information
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| name | glutathione-disulfide reductase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
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| comment | Note that this function was formerly EC:1.6.4.2.
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| subset | gosubset_prok
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| synonym | "glutathione reductase (NADPH) activity" EXACT []
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| synonym | "glutathione reductase activity" EXACT []
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| synonym | "glutathione S-reductase activity" EXACT [EC:1.8.1.7]
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| synonym | "glutathione-disulphide reductase activity" EXACT []
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| synonym | "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7]
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| synonym | "GSH reductase activity" EXACT [EC:1.8.1.7]
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| synonym | "GSSG reductase activity" EXACT [EC:1.8.1.7]
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| synonym | "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7]
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| synonym | "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7]
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| synonym | "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7]
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| synonym | "oxidized glutathione reduction" RELATED []
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| xref | EC:1.8.1.7
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| xref | MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
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| xref | Reactome:10508 "glutathione-disulfide reductase activity"
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| is_a | GO:0015038 ! glutathione disulfide oxidoreductase activity
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| is_a | GO:0016209 ! antioxidant activity
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| is_a | GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor
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