| id | GO:0004418 Detailed information
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| name | hydroxymethylbilane synthase activity
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| namespace | molecular_function
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| def | "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13188]
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| comment | Note that this function was formerly EC:4.3.1.8.
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| subset | gosubset_prok
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| synonym | "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61]
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| synonym | "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61]
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| synonym | "HMB-synthase activity" EXACT [EC:2.5.1.61]
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| synonym | "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61]
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| synonym | "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61]
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| synonym | "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61]
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| synonym | "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61]
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| synonym | "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61]
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| synonym | "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61]
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| synonym | "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61]
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| synonym | "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61]
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| xref | EC:2.5.1.61
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| xref | KEGG:R00084
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| xref | MetaCyc:OHMETHYLBILANESYN-RXN
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| xref | Reactome:11374 "hydroxymethylbilane synthase activity"
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| xref | RHEA:13188
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| is_a | GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
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