Queried GO terms:

  idGO:0005943   Detailed information
  name1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
  def"A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495]
  synonym"1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT []
  synonym"class IA PI3K complex" EXACT []
  synonym"phosphoinositide 3-kinase complex, class IA" EXACT []
  is_aGO:0005942 ! phosphatidylinositol 3-kinase complex

Monarch genes with this GO terms: