| New model in OGS2.0 | DPOGS204778 |
|---|---|
| Genomic Position | scaffold2303:+ 6585-17746 |
| See gene structure | |
| CDS Length | 2199 |
| Paired RNAseq reads | 2810 |
| Single RNAseq reads | 6756 |
| Migratory profiles | Query via corresponding ESTs |
| Best Bmobyx hit | BGIBMGA013714 (0.0) |
| Best Drosophila hit | neprilysin 2 (8e-98) |
| Best Human hit | endothelin-converting enzyme 1 isoform 4 (3e-106) |
| Best NR hit (blastp) | PREDICTED: similar to Endothelin-converting enzyme 1 [Tribolium castaneum] (0.0) |
| Best NR hit (blastx) | hypothetical protein TcasGA2_TC010845 [Tribolium castaneum] (0.0) |
| GeneOntology terms | GO:0001666 response to hypoxia GO:0001921 positive regulation of receptor recycling GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0005624 membrane fraction GO:0005768 endosome GO:0005769 early endosome GO:0005886 plasma membrane GO:0006508 proteolysis GO:0006915 apoptosis GO:0007507 heart development GO:0008233 peptidase activity GO:0009897 external side of plasma membrane GO:0010814 substance P catabolic process GO:0010815 bradykinin catabolic process GO:0010816 calcitonin catabolic process GO:0016021 integral to membrane GO:0016485 protein processing GO:0016486 peptide hormone processing GO:0030141 stored secretory granule GO:0031982 vesicle GO:0033093 Weibel-Palade body GO:0034959 endothelin maturation GO:0042447 hormone catabolic process GO:0042733 embryonic digit morphogenesis GO:0042803 protein homodimerization activity GO:0043583 ear development GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway GO:0046872 metal ion binding GO:0048471 perinuclear region of cytoplasm GO:0051605 protein maturation by peptide bond cleavage GO:0060037 pharyngeal system development |
| InterPro families | IPR008753 Peptidase M13 IPR018497 Peptidase M13, neprilysin, C-terminal IPR000718 Peptidase M13, neprilysin |
| Orthology group | MCL18041 |
Nucleotide sequence:
ATGAACACAGGAGAGACGAAGAAGCTGAGAGAGATAGCTCGCACTGTGCGCTGTTCGTGG
GTGGTGATCGTATCCCTGGGCTTGTCCCTGGCGGTGCTGGCGGTGTACACCACGGTCGTG
GTGGTGGTAGACCTTAAAGCACCCAAACCCTGCCTCACTGAAGTGTGCGTCAATACAGCG
TCGAGAGTACTAGCAGCATTAAACAAGAGCGTGGATCCCTGCGACGACTTCTACGAGTTC
GCATGTGGTGGGTGGATCGAGAAGAACCCTGTCCCGGAGTGGGCGACCTCCTGGGATCAG
CTTGCCATCCTGCGAGAGAAACTGGTCACTGACCTGAGGGAACTGTTGGAAGACAAAAAC
GACCACGGCCTGCCTAAGAGCGTGCTCAAAGCTAAAGCCCTCTACCGCACTTGTATGGAT
GTTGACAAGCTAGAGGTGTACGGAACCGCGCCCATCACGGATCTGTTGCTACAACTAGGC
CTTCCTCCAACGCCCCCTTCCGTGTCCAGTGATAACTTCTCGTGGGAGCAGGTGTCTGGG
CGCGCCCGCAGGACTCTCGGTCTCAGTGTTCTGCTGAGCGTTCAGGTCGCTGAGGATGTG
AGGAACACTAGCAGGAACAGGGTCGTGTTGGAGCAGGTATCTCCAGGGTTCAGCGATCGT
TACCTGCGCCAGGCGGACAAGTTCTCGTTCGAGTTGGAGCAGTACCGGATCTACATCACG
TCAATGATCAAAGCCTTCCATCCCGACACGGACGCGGAACGCTTCGCCGACGACATTATA
GAATTCAGCAAGACTCTGGCTGGCATCATGACGCCGGTGGAGGTTCGTCGCAGCGGCACT
CACCTGTTCCACGAGCTGAGTGTGACTCAGCTGCTGGGAGGGAACGGAGCTCCTCCTGAA
TGGCACCAGCACGACTGGCAGAAGTATATAGACCTGGTGTTCTCCAACACGAGCGTGTCT
CTGACGGACGGCGACCGAGTCATCGTGATGGACCTGCCCTACCTGCACCGCCTGGCCGGC
ACGCTGGCTCGTACCGACCCACTCATCACAGAGCGCTTCCTGTGGTGGAGCGTGTTCTCG
ACCGTGGCTCCGATGACTCGCGCCATATTTCGGACCCTCGGGTTCGAGTTCAGCCGCGCG
GCCTGGGGCCTGCGGGCCCGCGTCGACCGCCACAAGGCCTGCGCCGCCAACGTCAACGCC
AACTACGGCCTCGCGCTCAGCTACCTCTACGTCAATAAACACTTCGATGAACACGAACGC
GAAAAGGCTATAGAAATGATCGAGGACGTCCGCGAGTCGTTCGCGGAGGCGGCTCGCTCC
CTGCCCTGGATGGACGACGGCACGCGGGACACGGCGCTGCACAAGCTGAGGGCCATACGG
ACCTTCGTGGGCTTCCCCGCCTGGCTCATGGACACACACAAGCTGGACCGACATTACGAA
CACGTGGAGGTGGTGGAGGGGAACCTGTTCGAGTCATACTTGAAGCTGACCTGGGCCACC
GTCAAGAAGTCACTGGAGTCTCTGAGAGAGACGCCGGACAGGAACAGGTGGGTCGCGACC
GCCACCACAGTCAATGCCTTCTATTCAGCAACACTTAATTCAGTCACATTCCCGGCTGGC
ATCTTACAACCACCTTTTTACGGAAATGGAATCGAGGCAATAAACTACGGATCCATCGGA
GCCATCATGGGTCATGAAGTGACACACGGCTTCGACGATCAAGGTCGTCGGTACGATTCA
GACGGCAATCTAGCGTCGTGGTGGTCACGGGAAACGCTGGAGCAGTACCAGGCGCGGGTG
AGGTGCATCGTGGAGCAATACGACCAGTACGGCCTGCCGCAGCTGGCCGGGTATAACGTG
CACGGGTTCAACACGCAGGGGGAAAATATCGCCGACAACGGGGGCCTGCGGGCCGCGCTC
CGGGCTTACCGCAGGCACGAGGCGCGCGCCGGGCGGGCCGCCCTCCTGCCAGGTCTCCCG
GGACACACTCCCACACAACTCTTCTTCCTCGGATTCGCCCAGATATGGTGCGGGAACTCC
ACTACGGGGGCGCTGAAATCGAAAATGGTGGAAGGCGTCCACAGTCCTAACAAAATAAGA
GTCATAGGGACCTTGAGCAATTCCAAGGAGTTCTCAGAAGCTTGGAAATGTCCTCTGGGG
TCTCCCATGAACCCAGAACACAAGTGCGTTTTGTGGTAA
Protein sequence:
MNTGETKKLREIARTVRCSWVVIVSLGLSLAVLAVYTTVVVVVDLKAPKPCLTEVCVNTA
SRVLAALNKSVDPCDDFYEFACGGWIEKNPVPEWATSWDQLAILREKLVTDLRELLEDKN
DHGLPKSVLKAKALYRTCMDVDKLEVYGTAPITDLLLQLGLPPTPPSVSSDNFSWEQVSG
RARRTLGLSVLLSVQVAEDVRNTSRNRVVLEQVSPGFSDRYLRQADKFSFELEQYRIYIT
SMIKAFHPDTDAERFADDIIEFSKTLAGIMTPVEVRRSGTHLFHELSVTQLLGGNGAPPE
WHQHDWQKYIDLVFSNTSVSLTDGDRVIVMDLPYLHRLAGTLARTDPLITERFLWWSVFS
TVAPMTRAIFRTLGFEFSRAAWGLRARVDRHKACAANVNANYGLALSYLYVNKHFDEHER
EKAIEMIEDVRESFAEAARSLPWMDDGTRDTALHKLRAIRTFVGFPAWLMDTHKLDRHYE
HVEVVEGNLFESYLKLTWATVKKSLESLRETPDRNRWVATATTVNAFYSATLNSVTFPAG
ILQPPFYGNGIEAINYGSIGAIMGHEVTHGFDDQGRRYDSDGNLASWWSRETLEQYQARV
RCIVEQYDQYGLPQLAGYNVHGFNTQGENIADNGGLRAALRAYRRHEARAGRAALLPGLP
GHTPTQLFFLGFAQIWCGNSTTGALKSKMVEGVHSPNKIRVIGTLSNSKEFSEAWKCPLG
SPMNPEHKCVLW